Physician-scientist with a passion for genomics and computational biology

My research has evolved from traditional bench work to big data and computational analysis, with a focus on chromatin organization. My ultimate goal is to make meaningful contributions to our understanding of biology and disease through the lens of genomics.

MD, Medicine

Perelman School of Medicine

Philadelphia, PA

2023

PhD, Genetics and Epigenetics

University of Pennsylvania

Philadelphia, PA

2021

BS, Molecualr and Cellular Biology

The Johns Hopkins Universitry

Baltimore, MD

2012

Doctoral Student

University of Pennsylvania

Philadelphia, PA

2021

• Principal Investigator: Rajan Jain, MD
• Co-Mentor: Jonathan A. Epstein, MD

Undergraduate Researcher

The Johns Hopkins University

Baltimore, MD

2015

• Principal Investigator: Haig Kazazian, MD

Undergraduate Researcher

University of Pennsylvania

Philadelphia, PA

2015

• Principal Investigator: Michael Marks, PhD

Postbaccalaureate Research Fellow

National Institutes of Health

Bethesda, MD

2014

• Principal Investigator: William Gahl, MD, PhD
• Co-Mentor: Camilo Toro, MD

BRD4 orchestrates genome folding to promote neural crest differentiation

Nature Genetics

N/A

2021

• Ricardo Linares Saldana, Wonho Kim, Nikhita A. Bolar, Haoyue Zhang, Bailey A. Koch-Bojalad, Sora Yoon, Parisha P. Shah, Ashley Karnay, Daniel S. Park, Jennifer M. Luppino, Son C. Nguyen, Arun Padmanabhan, Cheryl L. Smith, Andrey Poleshko, Qiaohong Wang, Li Li, Deepak Srivastava, Golnaz Vahedi, Gwang Hyeon Eom, Gerd A. Blobel, Eric F. Joyce, Rajan Jain

Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro

Cell Systems

N/A

2021

• Ian A. Mellis, Hailey I. Edelstein, Rachel Truitt, Yogesh Goyal, Lauren E. Beck, Orsolya Symmons, Margaret C. Dunagin, Ricardo Linares Saldana, Parisha P. Shah, Juan A. Pérez-Bermejo, Arun Padmanabhan, Wenli Yang, Rajan Jain, Arjun Raj

A transcriptional switch governs fibroblast activation in heart disease

Nature

N/A

2021

• Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, Arun Padmanabhan, Lin Ye, Joshua G. Travers, Barbara Gonzalez-Teran, Ana Catarina Silva, Qiming Duan, Sanjeev S. Ranade, Franco Felix, Ricardo Linares Saldana, Li Li, Clara Youngna Lee, Nandhini Sadagopan, Angelo Pelonero, Yu Huang, Gaia Andreoletti, Rajan Jain, Timothy A. McKinsey, Michael G. Rosenfeld, Casey A. Gifford, Katherine S. Pollard, Saptarsi M. Haldar, Deepak Srivastava

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

Cell Stem Cell

N/A

2021

• Parisha P. Shah, Wenjian Lv, Joshua H. Rhoades, Andrey Poleshko, Deepti Abbey, Matthew A. Caporizzo, Ricardo Linares Saldana, Julie G. Heffler, Nazish Sayed, Dilip Thomas, Qiaohong Wang, Liam J. Stanton, Kenneth Bedi, Michael P. Morley, Thomas P. Cappola, Anjali T. Owens, Kenneth B. Margulies, David B. Frank, Joseph C. Wu, Daniel J. Rader, Wenli Yang, Benjamin L. Prosser, Kiran Musunuru, Rajan Jain

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

Circulation

N/A

2020

• Arun Padmanabhan, Michael Alexanian, Ricardo Linares Saldana, Bárbara González Terán, Gaia Andreoletti, Yu Huang, Andrew J. Connolly, Wonho Kim, Austin Hsu, Qiming Duan, Sarah A.B. Winchester, Franco Felix, Juan A. Perez-Bermejo, Qiaohong Wang, Li Li, Parisha P.Shah, Saptarsi M. Haldar, Rajan Jain, Deepak Srivastava

Identification of a molecular basis for the juvenile sleep state

eLife

N/A

2020

• Leela Chakravarti Dilley, Milan Szuperak, Naihua N Gong, Charlette E Williams, Ricardo Linares Saldana, David S Garbe, Mubarak Hussain Syed, Rajan Jain, Matthew S Kayser

Targeting cardiac fibrosis with engineered T cells

Nature

N/A

2019

• Haig Aghajanian, Toru Kimura, Joel G. Rurik, Aidan S. Hancock, Michael S. Leibowitz, Li Li, John Scholler, James Monslow, Albert Lo, Wei Han, Tao Wang, Kenneth Bedi, Michael P. Morley, Ricardo Linares Saldana, Nikhita A. Bolar, Kendra McDaid, Charles-Antoine Assenmacher, Cheryl L. Smith, Dagmar Wirth, Carl H. June, Kenneth B. Margulies, Rajan Jain, Ellen Puré, Steven M. Albelda, Jonathan A. Epstein

Early lineage specification defines alveolar epithelial ontogeny in the murine lung

Proceedings of the National Academy of Sciences

N/A

2019

• David B. Frank, Ian J. Penkala, Jarod A. Zepp, Aravind Sivakumar, Ricardo Linares Saldana, William J. Zacharias, Katharine G. Stolz, Josh Pankin, MinQi Lu, Qiaohong Wang, Apoorva Babu, Li Li, Su Zhou, Michael P. Morley, Rajan Jain, Edward E. Morrisey

Centromere inheritance through the germline

Chromosoma

N/A

2017

• Arunika Das, Evan M. Smoak, Ricardo Linares Saldana, Michael A. Lampson, Ben E. Black

BLOC-1 Brings Together the Actin and Microtubule Cytoskeletons to Generate Recycling Endosomes

Current Biology

N/A

2016

• Cédric Delevoye, Xavier Heiligenstein, Léa Ripoll, Floriane Gilles-Marsens, Megan K. Dennis, Ricardo Linares Saldana, Laura Derman, Avanti Gokhale, Etienne Morel, Victor Faundez, Michael S. Marks, Graça Raposo

NRSA F31 Grant Award

National Institutes of Health

N/A

2022 - 2019

Research Fellowship

The Center for Engineering MechanoBiology at UPenn

N/A

2021 - 2017

Research Travel Awards

Society for Advancement of Chicanos/Hispanics and Native Americans in Science, Graduate and Professional Student Assembly, and Biomedical Graduate Studies at UPenn

N/A

2018 - 2017