I am physician-scientist with a passion for utilizing genomics to uncover the intricate mechanisms underlying biology and disease. My research has evolved from traditional bench work to big data and computational analysis, with a focus on chromatin organization. My ultimate goal is to make meaningful contributions to our understanding of complex diseases through the lens of genomics.

During my graduate studies, I was supported by a NIH F31 award and worked closely with Drs. Rajan Jain and Jon Epstein to investigate the role of chromatin organization in gene regulation during cell differentiation. This research led to several publications, including two first-author papers in prestigious journals such as Nature Genetics and Circulation.

Outside of the lab and medicine, my family is my top priority. I cherish spending time with my wife and daughter and watching our little one grow and develop. In addition, I love exploring nature through hiking, camping, and mushroom foraging.

Download my curriculum vitae .

Access my genomics analysis Shiny server.

Explore Hi-C data in my HiGlass server .

Interests
  • Genetics & Epigenetics
  • Chromatin organization
  • Computational genomics
  • Data analysis & visualization
  • Disease biology
Education

  • MD, Pereleman School of Medicine, expected 2023

    University of Pennsylvania

  • PhD, Genetics and Epigenetics, 2021

    University of Pennsylvania

  • BS, Molecular and Cellular Biology, 2012

    The Johns Hopkins University

Computational Skills

Bash

Shell Scripting | CLI | Sys Adm

R

Statistical Analysis | Visualization | R Shiny

Python
High Performance Computing
Awk

Text Processing | Data Formating | Regex

Next-Gen Sequencing

Data Generation & Analysis | Bioconda

Research Experience

 
 
 
 
 
University of Pennsylvania
Postdoctoral Researcher
University of Pennsylvania
March 2023 – Present Philadelphia, PA
Principal Investigator: Rajan Jain, MD
 
 
 
 
 
University of Pennsylvania
Doctoral Student in Genetics & Epigenetics
University of Pennsylvania
November 2016 – June 2021 Philadelphia, PA
Principal Investigator: Rajan Jain, MD. Co-Mentor: Jonathan A. Epstein, MD
 
 
 
 
 
National Institutes of Health
Postbaccalaureate Research Fellow
National Institutes of Health
August 2012 – May 2014 Bethesda, MD
Principal Investigator: William Gahl, MD, PhD Co-Mentor: Camilo Toro, MD
 
 
 
 
 
The Johns Hopkins University
Undergraduate Researcher
The Johns Hopkins University
January 2012 – May 2012 Baltimore, MD
Principal Investigator: Haig Kazazian, MD
 
 
 
 
 
University of Pennsylvania
Undergraduate Researcher
University of Pennsylvania
June 2011 – August 2011 Philadelphia, PA
Principal Investigator: Michael Marks, PhD

Recent Publications

Ricardo Linares Saldana, Wonho Kim, Nikhita A. Bolar, Haoyue Zhang, Bailey A. Koch-Bojalad, Sora Yoon, Parisha P. Shah, Ashley Karnay, Daniel S. Park, Jennifer M. Luppino, Son C. Nguyen, Arun Padmanabhan, Cheryl L. Smith, Andrey Poleshko, Qiaohong Wang, Li Li, Deepak Srivastava, Golnaz Vahedi, Gwang Hyeon Eom, Gerd A. Blobel, Eric F. Joyce, Rajan Jain (2021). BRD4 orchestrates genome folding to promote neural crest differentiation. Nature Genetics.

PDF Source Document DOI

Ian A. Mellis, Hailey I. Edelstein, Rachel Truitt, Yogesh Goyal, Lauren E. Beck, Orsolya Symmons, Margaret C. Dunagin, Ricardo Linares Saldana, Parisha P. Shah, Juan A. Perez-Bermejo, Arun Padmanabhan, Wenli Yang, Rajan Jain, Arjun Raj (2021). Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in~vitro. Cell Systems.

PDF Source Document DOI

Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, Arun Padmanabhan, Lin Ye, Joshua G. Travers, Barbara Gonzalez Teran, Ana Catarina Silva, Qiming Duan, Sanjeev S. Ranade, Franco Felix , Ricardo Linares Saldana, Li Li, Clara Youngna Lee, Nandhini Sadagopan, Angelo Pelonero, Yu Huang, Gaia Andreoletti, Rajan Jain, Timothy A. McKinsey, Michael G. Rosenfeld, Casey A. Gifford, Katherine S. Pollard, Saptarsi M. Haldar, Deepak Srivastava (2021). A transcriptional switch governs fibroblast activation in heart disease. Nature.

PDF Source Document DOI

Parisha P. Shah, Wenjian Lv, Joshua H. Rhoades, Andrey Poleshko, Deepti Abbey, Matthew A. Caporizzo, Ricardo Linares Saldana, Julie G. Heffler, Nazish Sayed, Dilip Thomas, Qiaohong Wang, Liam J. Stanton, Kenneth Bedi, Michael P. Morley, Thomas P. Cappola, Anjali T. Owens, Kenneth B. Margulies, David B. Frank, Joseph C. Wu, Daniel J. Rader, Wenli Yang, Benjamin L. Prosser, Kiran Musunuru, Rajan Jain (2021). Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell.

PDF Source Document DOI

Arun Padmanabhan, Michael Alexanian, Ricardo Linares Saldana, Barbara Gonzalez Teran, Gaia Andreoletti, Yu Huang, Andrew J. Connolly, Wonho Kim, Austin Hsu, Qiming Duan, Sarah A.B. Winchester, Franco Felix , Juan A. Perez-Bermejo, Qiaohong Wang, Li Li, Parisha P. Shah, Saptarsi M. Haldar, Rajan Jain, Deepak Srivastava (2020). BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation.

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