I am physician-scientist with a passion for utilizing genomics to uncover the intricate mechanisms underlying biology and disease. My research has evolved from traditional bench work to big data and computational analysis, with a focus on chromatin organization. My ultimate goal is to make meaningful contributions to our understanding of complex diseases through the lens of genomics.
During my graduate studies, I was supported by a NIH F31 award and worked closely with Drs. Rajan Jain and Jon Epstein to investigate the role of chromatin organization in gene regulation during cell differentiation. This research led to several publications, including two first-author papers in prestigious journals such as Nature Genetics and Circulation.
Outside of the lab and medicine, my family is my top priority. I cherish spending time with my wife and daughter and watching our little one grow and develop. In addition, I love exploring nature through hiking, camping, and mushroom foraging.
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MD, Pereleman School of Medicine, expected 2023
University of Pennsylvania
PhD, Genetics and Epigenetics, 2021
University of Pennsylvania
BS, Molecular and Cellular Biology, 2012
The Johns Hopkins University
Shell Scripting | CLI | Sys Adm
Statistical Analysis | Visualization | R Shiny
Text Processing | Data Formating | Regex
Data Generation & Analysis | Bioconda
Here we define a role for bromodomain-containing protein 4 (BRD4) in 3D genome organization and its interaction with the cohesin loader NIPBL. Results of our experiments demonstrate that BRD4 depletion results in decreased NIPBL binding to cromatin, compromised genome folding and loop extrusion, and impared cell differentiation.